Liposomes are composite structures that aid active ingredients to penetrate multiple layers of the skin.
Extensive research has been conducted to determine to best way to deliver actives to various depths of the stratum corneum. One conclusion of this research has shown the preferred mechanism for delivering active ingredients into the skin is by incorporating liposome into personal care products.
Liposomes are microscopic. Spherical in shape, these self-enclosed capsules range in size from 150 – 3500 nanometres in diametre.
A liposome’s lipid bilayer sequesters water-soluble materials but prevents ions, proteins and other molecules from diffusing in areas where they don’t belong. As it resembles the basic structure of cellular membranes, this and its amphiphilic* nature allows the liposome to penetrate and travel deeper through the epidermal barrier than free materials, creating beneficial interaction with skin cells.
When non-encapsulated materials are placed on the skin, a range of factors determine the fate of the material. Stability, solubility, lipophilicity, and size are all obstacles the active must overcome to penetrate the epidermal barrier.
Although found in both unilamellar and multilamellar forms, only the unilamellar vesicles offer the stability needed to be incorporated into personal care products.
Proven delivery system
Since their discovery in 1961, vast amounts of research have detailed liposome mechanisms in drug delivery, personal care, and even food. In fact, Dior first introduced the use of liposomes in its Capture range of skincare in 1986. It marketed it as containing a Liposome Complex which claimed to effectively convey active ingredients into the skin in microcapsules 300 times smaller than a normal cell.
The Liposomes’ delivery system produces multiple benefits. It:
- Enhances the penetration of actives to increase their efficacy
- Offers time release mechanisms
- Protects and delivers unstable ingredients
- Opens the door to target specific cells.
*molecules having a polar water-soluble group attached to a water-insoluble hydrocarbon chain
Information from Active Concepts